ReGlow Micro-Infusion System
Engineering Rationale, Formula Mechanism & Safety Audit
The 500 Dalton Barrier
The Biological Fact: The skin's Stratum Corneum acts like a waterproof "Brick and Mortar" wall. Scientific consensus (The Dalton Rule) states that molecules larger than 500 Daltons cannot passively penetrate this barrier.
The Solution: The ReGlow device uses a 0.295mm hollow needle array to create physical micro-conduits, bypassing the lipid barrier entirely.
Figure 1: Permeation Efficiency Model
1. Precision Engineering
Anatomical Targeting of the Dermo-Epidermal Junction (DEJ)
Depth Calibration
Target: Papillary Dermis
The 295µm length penetrates the viable epidermis to reach fibroblast-rich zones without hitting the deep reticular dermis.
Safety: Pain-Free Zone
By stopping before 400µm, the needle avoids the deep vascular plexus and major nociceptors, ensuring a painless procedure.
2. Formula Mechanism
REGEN:STEM+ Anti-Aging Complex
Signal Peptides
Collagen AgonistsINCI: Palmitoyl Tripeptide-1, 7
Tricks the skin into thinking it is damaged, triggering a repair response.
Acts as "matrikines"—messengers that instruct fibroblasts to synthesize new Collagen.
Neuro-Inhibitors
Line RelaxersINCI: Acetyl Hexapeptide-8
Softens expression lines similar to a mild botulinum effect.
Destabilizes the SNARE complex to inhibit muscle contraction signals.
Cellular Carriers
Exosomes & Stem CellsINCI: Ginseng EVs, Malus Domestica
Delivers antioxidant cargo deep into cells promoting longevity.
Lipid-bilayer vesicles (~130nm) fuse with cell membranes to drop off cargo directly.
Bioactive Efficacy Profile
The "Interstitial Reservoir"
The Mechanism: The serum is engineered with a specific viscosity of 258 mPa·s.
What this means: It is too thick to wash away instantly but fluid enough to flow through needles. Upon injection, it forms a "depot" in the papillary dermis.
The Result: Sustained release of actives over 24-48 hours.
3. Data Verification Audit
Source: Stability Report 2024/02/15 & COA Batch HM20250820
