Peptide Serum With Hyaluronic Acid: Where It Fits in a Skincare Routine

Peptide serums are popular because they can combine lightweight hydration with ingredients selected to support smoother- and firmer-looking skin. The ReGlow Peptide Serum combines peptides including Hexapeptide-11 with hyaluronic acid and Sodium PCA in a lightweight serum format.

What Is a Peptide Serum?

Peptides are short chains of amino acids used in cosmetic skincare formulas. Different peptides are selected for different formulation goals, so it is more useful to look at the complete formula than to treat every peptide serum as identical.

Why Pair Peptides With Hyaluronic Acid?

Hyaluronic acid is a humectant used to support skin hydration. Combining it with peptides gives the serum both a hydration-focused role and a smoother-looking skin focus without requiring multiple separate serums.

Where Does Peptide Serum Go in the Routine?

Apply a lightweight serum after cleansing and toner, then follow with moisturizer. A simple order is:

1. Cleanser
2. Toner, if used
3. Peptide serum
4. Moisturizer
5. Daytime sun protection

Can You Use a Peptide Serum in the Morning?

Yes. A peptide and hyaluronic acid serum can fit into either a morning or evening routine. In the morning, follow with moisturizer and appropriate sun protection.

Can You Use Peptides With a Retinol Alternative?

Many routines can include both, but you do not need to layer every active in one application. One simple option is to use the peptide serum in the morning and a bakuchiol-based retinol-alternative oil in the evening.

For more on bakuchiol, see our guide to natural retinol alternatives.

Peptide Serum FAQ

Do peptides replace moisturizer?

Not necessarily. A serum is typically lighter than a moisturizer, so many people use both.

Can dry skin use a peptide serum?

A formula containing hyaluronic acid and Sodium PCA can fit well into a hydration-focused routine.

Should peptide serum go before or after facial oil?

Apply the lightweight serum first and oil later in the routine.

Explore the ReGlow Peptide Serum.